Amy Orciari Herman, Edited by David G. Fairchild, MD, MPH, and Jaye Elizabeth Hefner, MD

In primary prevention of cardiovascular disease in adults — the group recommends low-to-moderate-dose statins for adults aged 40–75 without histories of cardiovascular disease who have at least one CVD risk factor (dyslipidemia, diabetes, hypertension, smoking) and a 10-year risk for a cardiovascular event of 10% or greater (grade B recommendation).

For those with a 10-year risk of 7.5–10%, the benefits of preventive therapy are likely less, and “clinicians may choose to offer” a statin (grade C recommendation). To assess 10-year risk, the USPSTF recommends using the American College of Cardiology/American Heart Association 2013 risk calculator, which requires lipid screening (see link below).

In addition, for adults aged 76 and older, the group says that the evidence is insufficient to weigh statins’ benefits and harms (I statement).


USPSTF draft recommendation statement on statin therapy (Free)

USPSTF draft recommendation statement on lipid screening (Free) USPSTF grade definitions (Free)

ACC/AHA risk calculator (Free)